Polymorphism and bistability in adherent cells

Simple item page
dc.contributor.areaPhysicsen_US
dc.contributor.areaMathematicsen_US
dc.contributor.authorShiladitya Banerjee
dc.contributor.authorLuca Giomi
dc.date.accessioned2013-02-05T08:04:37Z
dc.date.available2013-02-05T08:04:37Z
dc.date.issued2012-09-18
dc.description6 pages, 4 figures, submitteden_US
dc.description.abstractThe optimal shapes attained by contractile cells on adhesive substrates are determined by the interplay between intracellular forces and adhesion with the extracellular matrix. We model the cell as a contractile film bounded by an elastic cortex and connected to the substrate via elastic links. When the adhesion sites are continuously distributed, optimal cell shape is constrained by the adhesion geometry, with a spread area sensitively dependent on the substrate stiffness and contractile tension. For discrete adhesion sites, equilibrium cell shape is convex at weak contractility, while developing local concavities at intermediate values of contractility. Increasing contractility beyond a critical value, controlled by mechanical and geometrical properties of adhesion, cell boundary undergoes a discontinuous transition to a star-shaped configuration with cusps and protrusions, accompanied by a region of bistability and hysteresis.en_US
dc.identifier.urihttps://openscience.sissa.it/handle/1963/6446
dc.language.isoenen_US
dc.miur.area2en_US
dc.publisherSISSAen_US
dc.relation.ispartofseriesarXiv:1209.4004;
dc.subject.keywordCell adhesion, cell shape, mechanotransduction, actinen_US
dc.subject.miurFIS/02 FISICA TEORICA, MODELLI E METODI MATEMATICI
dc.titlePolymorphism and bistability in adherent cellsen_US
dc.typePreprinten_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1209.4004v1.pdf
Size:
1022.67 KB
Format:
Adobe Portable Document Format
Description:
File downloaded from arXiv.org
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Preprints